Decreased Uptake and Enhanced Mitochondrial Protection Underlie Reduced Toxicity of Nanoceria in Human Monocyte-Derived Macrophages
نویسندگان
چکیده
منابع مشابه
Quantification and comparison of TLR2 activity in monocyte-derived macrophages of zebu and crossbred cattle
The present study was conducted to quantify and compare TLR2 (toll-like receptor 2) activity in monocyte-derived macrophages of zebu (Tharparkar) and crossbred (Holstein-Friesian × Jersey × Brown Swiss × Hariana) cattle. The cells were either induced with Pam3CSK4 or kept as control. The TLR2 activity was quantified in terms of IκB-α inhibitory subunit (NFKBIA) messenger RNA (mRNA) copies...
متن کاملInteraction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages.
The aim of this work was to investigate the possible mechanisms for uptake by human monocyte-derived macrophages (HMDM) of low density lipoprotein (LDL) pretreated with human arterial chondroitin-6-SO4-rich proteoglycan (LDL-PG). HMDM were incubated with 125I-labeled tyramine cellobiose-labeled LDL-PG, native LDL, and acetylated LDL (Ac-LDL). The results showed that two to four times more LDL-P...
متن کاملreduced phagocytic capacity of blood monocyte/macrophages in tuberculosis patients is further reduced by smoking
tuberculosis (tb) and tobacco use are two major alarming global health issues posing immense threats to human populations. mycobacterium tuberculosis (mtb) by activation of macrophages could induce the sequences of cells activation and releases of inflammatory cytokines such as cxcl-8, il-12 and tnf-α which in turn induces the immune system network. however no information is available on other ...
متن کاملMMP9 production by human monocyte-derived macrophages is decreased on polymerized type I collagen.
The production of matrix metalloproteinases (MMPs), such as MMP9, by macrophages may be a critical factor in the rupture of unstable atherosclerotic plaques and aortic aneurysms. Therefore, we studied the role of matrix and soluble cytokines in the regulation of monocyte/macrophage expression of MMP9. Although freshly isolated monocytes synthesize little MMP9, cells cultured on tissue-culture p...
متن کاملMitochondrial Toxicity of Depleted Uranium: Protection by Beta-Glucan
Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomedical Nanotechnology
سال: 2016
ISSN: 1550-7033
DOI: 10.1166/jbn.2016.2320